Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Atrioventricular block first degree
ADR ID BADD_A00378
ADR Hierarchy
02      Cardiac disorders
02.03      Cardiac arrhythmias
02.03.01      Cardiac conduction disorders
02.03.01.004      Atrioventricular block first degree
Description A disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds. [CTCAE]
MedDRA Code 10003674
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
1st degree heart block | Atrioventricular block first degree | Atrioventricular conduction time prolonged | AV block first degree | First degree atrioventricular block | Heart block 1st degree | Heart block AV first degree | Heart block first degree
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Cytochrome P450 2D6P10635T57392
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01767Phosphonatoformate--
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01835Pregabalin--
BADD_D01856Propafenone0.004790%
BADD_D01857Propafenone hydrochloride--
BADD_D01867Propranolol0.001266%
BADD_D01888Quetiapine--
BADD_D01889Quetiapine fumarate--
BADD_D01921Regadenoson--
BADD_D01923Remifentanil hydrochloride--
BADD_D01933Ribavirin--
BADD_D01951Risperidone0.000536%
BADD_D01952Ritonavir--
BADD_D01977Rufinamide--
BADD_D02002Selegiline--
BADD_D02026Simvastatin0.000031%
BADD_D02031Sitaxentan--
BADD_D02060Sotalol--
BADD_D02062Sparfloxacin--
BADD_D02066Spironolactone0.000173%
BADD_D02214Ticagrelor0.001259%
BADD_D02217Tigecycline--
BADD_D02247Topiramate0.000478%
BADD_D02259Trandolapril--
BADD_D02260Trandolaprilat--
BADD_D02346Venlafaxine--
BADD_D02351Vernakalant hydrochloride--
BADD_D02389Ziprasidone hydrochloride--
BADD_D02391Ziprasidone mesylate--
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